Parirenyatwa (Pari) CRS is situated within the Parirenyatwa Group of Hospitals, Zimbabwe’s premier public referral hospital, comprised of a main hospital with both out-patient facilities and a 500-bed in-patient facility for adults and children, a maternity hospital, a psychiatric hospital, a Family Care Center, and an ophthalmologic specialty hospital. It is one of the University of Zimbabwe College of Health Science’s (UZCHS) two teaching hospitals. In 2002, local scientists established what is now known as the Pari CRS, recognizing the potential to conduct wide-ranging clinical studies with a diverse populace burdened with a high prevalence of infectious diseases, including HIV/AIDS, TB, and malaria. Pari CRS draws participants from across urban Harare’s 8 administrative districts, as well as from the surrounding urban and peri-urban areas. The City of Harare Health Department has a network of 12 primary care clinics from which the Pari CRS recruits research participants. Early NIH funding (2003) created the ACTG International Clinical Trials Unit at this site. Initially hosted within the UZCHS Department of Medicine, Pari CRS now occupies and conducts studies in three clinic locations at Parirenyatwa Hospital: the University of Zimbabwe Clinical Research Center (UZ-CRC), the Family Care Center Research Clinic, and the Parirenyatwa Kaposi Sarcoma Outpatient Clinic.
The CRS has well developed expertise and infrastructure to conduct high quality research in the following priority areas:
- Adult HIV therapeutic strategies, including HIV cure, non-infections co-morbidities, and the infectious co-morbidities of hepatitis and tuberculosis
- Strategies to address HIV and HIV-associated infections in pediatric and maternal populations
- Integrated HIV prevention strategies
Specialized Research Capacity
Parirenyatwa Kaposi Sarcoma Outpatient Clinic: Located in the main Parirenyatwa Hospital outpatient department, the Kaposi Sarcoma Outpatient Clinic has been operational since 1992, and attends to 100 patients weekly. Currently, ACTG A5263 and A5264 are being conducted from this clinic, which will conduct future studies on other HIV-related malignancies. There are four physician consultation rooms, a patient waiting area, and UZ-UCSF’s research-dedicated Aseptic Room for chemotherapy preparation, which contains a Biosafety Cabinet, Class II.
The CRS is also equipped with a Bone Mass Density (BMD) Scanner operated by two trained radiographers, a colposcopy machine, and cryo-gun machine.
On-Site Testing and Specimen Preparation
The CRS is also supported by 2 DAIDS-certified satellite laboratories located at the UZ-CRC (1) and the Family Care Centre (1). These laboratories conduct on-site testing for rapid HIV tests, wet mount, urine pregnancy tests, and dipstick urinalysis, and ensure that samples are collected and their integrity maintained until they reach the CTU Central Laboratory, 2kms away at UZCHS, where they are processed and stored. For more information on our centralized testing capacity, please see our Central Laboratory page.
The CRS has excellent support from its two DAIDS certified pharmacies, located at the UZ-CRC (1) and the Family Care Centre (1), as well as from UZ-UCSF Central Pharmacy; at the latter, study product for all pharmacies is stored. The CRS pharmacies ensure uninterrupted service for dispensing, adherence counseling, and optimum storage of study product and HIV primary care drugs, as dictated by the various DAIDS Network protocols. The Chemotherapy Aseptic Room is located within the main pharmacy of the main Parirenyatwa Hospital, which is 200 meters from the UZ-CRC clinic pharmacy. This facility supports current and future protocols that require chemotherapy drug preparations. For more information on our centralized pharmacy please see our Central Pharmacy page.
For inquiries related to Parirenyatwa CRS and the research it conducts, please contact Site Leader, James Hakim, MBChB, MMED, MMedScClinEpi, FRCP, FRCP